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Palladium doped PDA-coated hercynite as a highly efficient catalyst for mild hydrogenation of...
Nature· 13 hours agoHercynite magnetic nanoparticles were produced through the co-precipitation of ferrous and aluminum cations. The surface of hercynite was respectively coated with silica, 2,4,6-trichloro-1,3,5 ...
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 2 days agoCollectively, the present study suggested FTO-mediated KDM5B stabilization in the context of loss of Smad4 activate DLG1/YAP1 pathway to promote tumorigenesis by reprogramming lipid accumulation ...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 6 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic ...
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 6 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
Edge sites dominate the hydrogen evolution reaction on platinum nanocatalysts - Nature Catalysis
Nature· 4 days agoPt is the most active catalyst for the hydrogen evolution reaction in acidic media, but the precise nature of its active sites remains elusive. Now electrical transport spectroscopy and molecular ...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 3 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 13 hours agoThe role of SNRPE in HCC was performed multiple assays in vitro and in vivo. SNRPE-regulated alternative splicing was recognized by RNA-Seq and confirmed by multiple assays. We herein identified ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 3 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 5 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical ...
Higher surface folding of the human premotor cortex is associated with better long-term learning...
Nature· 13 hours agoA brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn & ...