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Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult...
Nature· 4 hours agoBetween May 2019 and August 2021, we conducted a prospective cohort study of 234 children aged 3–11 years in communities bordering Kibale National Park, Uganda, and 30 adults ...
3D genomic mapping reveals multifocality of human pancreatic precancers - Nature
Nature· 6 days agoQuantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
A disinhibitory microcircuit of the orbitofrontal cortex mediates cocaine preference in mice -...
Nature· 5 days agoBrevican of the perineuronal nets of PV neurons regulated SST-PV synapse strength, and the knockdown of Brevican alleviated cocaine preference. These results reveal a novel ...
Civil Suits Filed, April 1-April 11
The Sentinel Echo, London, Ky. via Yahoo News· 4 days agoKenneth Jasper Barger, foreclosure —J.G. Wentworthy Originations LLC v. S.R.; property rights —Delta Natural Gas Company Inc.
Coordinated chemokine expression defines macrophage subsets across tissues - Nature Immunology
Nature· 5 days agoJakubzick and colleagues show that interstitial macrophages across various tissues display similar coordinated chemokine signatures in humans and mice.
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients - British...
Nature· 3 days agoMoreover, R54 significantly reduced FOXP3-TSDR demethylation with DNMT1 and FOXP3 downregulation. R54 impairs Tregs function in primary RCC patients targeting PTEN/PI3K/AKT pathway, reducing ...
Estimating neutrosophic finite median employing robust measures of the auxiliary variable -...
Nature· 3 days agoUnlike traditional methods that yield single-valued outcomes, our estimators produce ranges, suggesting where the population parameter is likely to be. We present the suggested generalised estimator ...
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in...
Nature· 3 days agoHere, we report that Grin2b-mutant mice show behavioral sensory hypersensitivity and brain hyperconnectivity associated with the anterior cingulate cortex (ACC). Grin2b-mutant mice with < ...
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies - Cell...
Nature· 5 days agoNPM1 mutation through the inactivation of FOXM1 via FOXM1 relocalization to the cytoplasm confers more favorable treatment outcomes for AML patients, confirming FOXM1 as a ...
Strongest U.S. Challenge to Big Tech’s Power Nears Climax in Google Trial
New York Times· 5 days agoMcCabe has been covering the Google antitrust trial from Washington, D.C. The biggest U.S. challenge...
