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Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 1 day agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Enhanced quantum coherence of plasmonic resonances with a chiral exceptional points - Communications...
Nature· 2 days agoThe advent of non-Hermitian optics carries new possibilities in manipulating optical response, offering alternative ways to enhance the quantum coherence of plasmonic resonances. Based on a ...
Convergent evolution of fern nectaries facilitated independent recruitment of ant-bodyguards from...
Nature· 11 hours agoSome plants use nectar to attract ant bodyguards. Here, the authors use a cross-kingdom phylogenetic approach to find that ferns and angiosperms evolved nectaries in the Cretaceous, coinciding ...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 4 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic ...
Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model...
Nature· 4 days agoQUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
Large anomalous Hall conductivity induced by spin chirality fluctuation in an ultraclean frustrated...
Nature· 3 days agoMagnetic frustration of spins often leads to nontrivial spin textures and anomalous Hall responses, but typically below the magnetic transition temperature. The authors observe a giant unconventional ...
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 4 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish -...
Nature· 3 days agoWhen a pulsed laser interacts with tissue, the molecules in the sample get excited to a higher energy state and relax either nonradiatively, leading to thermal damage, or via de-excitation processes ...
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish...
Nature· 2 days agoA DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.
Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo - Molecular...
Nature· 6 days agoAutism Spectrum Disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is ...