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Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 13 hours agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing ...
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 13 hours agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened ...
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated...
Nature· 6 days agoPartially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 13 hours agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Foldamers controlled by functional triamino acids: structural investigation of α/γ-hybrid...
Nature· 5 days agoPeptide-like foldamers are known to be controlled by amide backbone hydrogen bonding, however, the influence of functional groups forming individual hydrogen-bond networks remains underexplored ...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 7 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
In vitro generation of genetic diversity for directed evolution by error-prone artificial DNA...
Nature· 6 days agoError-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
Excitable dynamics driven by mechanical feedback in biological tissues - Communications Physics
Nature· 6 days agoMany excitable systems share a common feedback motif, but how such feedback acts on biomechanical systems remains largely unexplored. By extending the cellular vertex models ...
Higher surface folding of the human premotor cortex is associated with better long-term learning...
Nature· 5 days agoA brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn & ...
Microbial polyphenol metabolism is part of the thawing permafrost carbon cycle - Nature Microbiology
Nature· 2 days agoDiverse microbial polyphenol transformations in thawing permafrost refute the theory that these compounds stabilize soil carbon across Arctic landscapes.