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Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 15 hours agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production ...
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCĪ“ mediates endothelial...
Nature· 15 hours agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 15 hours agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual...
Nature· 3 days agoIn-vitro cytotoxicity tests, DLS, TEM, FTIR, UV/Vis, SEM, and DSC studies assessed the formulations' physical and chemical properties. The Proteinase K enzyme was used to ...
Epitope binning for multiple antibodies simultaneously using mammalian cell display and DNA...
Nature· 2 days agoAn epitope binning platform based on mammalian cell surface display and DNA sequencing enables the simultaneous binning of multiple antibodies without the need for antibody production and purification.
Microbial polyphenol metabolism is part of the thawing permafrost carbon cycle - Nature Microbiology
Nature· 2 days agoDiverse microbial polyphenol transformations in thawing permafrost refute the theory that these compounds stabilize soil carbon across Arctic landscapes.
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 5 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 2 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 6 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
Fully-automated CT derived body composition analysis reveals sarcopenia in functioning...
Nature· 2 days agoDetermination of body composition (the relative distribution of fat, muscle, and bone) has been used effectively to assess the risk of progression and overall clinical outcomes in different ...