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KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 4 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
Higher surface folding of the human premotor cortex is associated with better long-term learning...
Nature· 3 days agoA brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn a challenging new motor skill during six weeks of practice.
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 5 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish -...
Nature· 7 days agoWhen a pulsed laser interacts with tissue, the molecules in the sample get excited to a higher energy state and relax either nonradiatively, leading to thermal damage, or via de-excitation processes ...
Large anomalous Hall conductivity induced by spin chirality fluctuation in an ultraclean frustrated...
Nature· 7 days agoMagnetic frustration of spins often leads to nontrivial spin textures and anomalous Hall responses, but typically below the magnetic transition temperature. The authors observe a giant unconventional ...
Exploring the pathways of drug repurposing and Panax ginseng treatment mechanisms in chronic heart...
Nature· 22 hours agoChronic Heart Failure (CHF) is a significant global public health issue, with high mortality and morbidity rates and associated costs. Disease modules, which are collections of disease-related ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 5 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver ...
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to...
Nature· 4 days agoCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 ( ...
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 7 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis...
Nature· 22 hours agoCancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication of CSCs is widely ...