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Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2...
Nature· 1 day agoImmunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer ...
Impairing hydrolase transport machinery prevents human melanoma metastasis - Communications Biology
Nature· 1 day agoAn in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.
Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice...
Nature· 1 day agoProdromal gut inflammation exacerbates Parkinson’s disease endophenotypes in mouse carriers of human LRRK2 G2019S in a sex-dependent manner, showing increased α-synuclein positive macrophages in the colon and brain microglia.
Fibroblasts’ secretome from calcified and non-calcified dermis in Pseudoxanthoma elasticum...
Nature· 5 hours agoAn in vitro study on fibroblasts from clinically affected or unaffected skin of patients with Pseudoxanthoma elasticum indicates that local microenvironment guides the level of matrix remodeling and the extent of elastic fiber calcification.
Sustained attention operates via dissociable neural mechanisms across different eccentric locations...
Nature· 5 hours agoIn primates, foveal and peripheral vision have distinct neural architectures and functions. However, it has been debated if selective attention operates via the same or different neural mechanisms ...
Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the...
Nature· 2 days agoEsophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive system. Hypoxia is a crucial player in tumor ferroptosis resistance. However, the molecular mechanism of ...
Soil microbiota and herbivory drive the assembly of tomato plant-associated microbial communities...
Nature· 3 days agoThis study shows that the soil microbial community and herbivory both influence the assembly of the plant-associated microbial communities, but their effects are generated through different mechanisms.
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated...
Nature· 1 day agoIn vitro studies were conducted in primary hippocampal neurons subjected to oxygen and glucose deprivation/-reoxygenation (OGD/R). We showed that the expression of PHLDA1 ...
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in...
Nature· 2 days agoPrimary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease with an unclear pathogenesis, and there is currently no approved drug for the treatment of this disease. Iguratimod ...
Deeds Recorded, Mar. 6-20
The Sentinel Echo, London, Ky. via Yahoo Finance· 6 days agoMay 9—Mar. 6 —Commonwealth of Kentucky Transportation Cabinet to Albert Robinson and Lucille Robinson, 1.28 acres and 0.04 acres on KY 30, $10,824 —Mark Howard and Debra Charlene McWhorter Howard ...