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Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag - Nature...
Nature· 5 days agoThe genome-wide landscape of Cas-induced double-strand breaks and end structures is profiled at nucleotide resolution.
There’s a highly contagious blight attacking CT orchards. How it causes a ‘devastating impact.’
Hartford Courant· 3 days agoFire blight, a bacteria that gets into the apple tree as it is flowering, wilts the apple tree’s...
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast...
Nature· 4 days agoSomatic copy number alterations (SCNAs) are prevalent in cancer and play a significant role in both tumorigenesis and therapeutic resistance. While focal SCNAs have been extensively studied, ...
A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human...
Nature· 5 days agoAs demand for organ transplants exceeds availability there has been an unmet need to extend preservation of deceased donor kidneys. Here, the authors show that a cell-free nutrient-supplemented ...
Engineered CD47 protects T cells for enhanced antitumour immunity - Nature
Nature· 3 days agoCombination of TCR or CAR T cells expressing the engineered CD47 variant 47E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance ...
Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis -...
Nature· 4 days agoMicroRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. However, the physiological functions of these non-coding RNAs in renal interstitial mesenchymal cells ...
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy...
Nature· 12 hours agoFor this study the following antibiotics were analyzed: ampicillin, amoxicillin-clavulanate cefepime, cefotaxime, cefoxitin, ceftazidime, aztreonam, imipenem, gentamicin, kanamycin,
EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous...
Nature· 4 days agoEP4 receptor enhances OSCC cell migration through increased Ca2+ signaling, linking to CALML6 and the CaMKK2 pathway. This process promotes mitochondrial function and metastasis, with CaMKK2 emerging as a potential target for OSCC treatment.
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC - Communications Biology
Nature· 5 days agoAn orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at ...
GLP-1-directed NMDA receptor antagonism for obesity treatment - Nature
Nature· 3 days agoUnimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.