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Mercury contamination is an invisible threat to declining migratory shorebirds along the East...
Nature· 5 days agoOver one-third of the sampled shorebirds along the East Asian-Australasian Flyway are facing Hg risk. Tringa genus in South China was at the highest risk. Feather Hg was best explained by feathers ...
Impairing hydrolase transport machinery prevents human melanoma metastasis - Communications Biology
Nature· 6 days agoAn in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.
Unveiling the electronic origin of lanthanide based Metal Organic Framework with ideal spin...
Nature· 4 days agoRecently ideal spin filtering ability was demonstrated in the Dy-L-Tar metal-organic framework. In this work the authors show that this unusual effect emerges from the asymmetric display of ...
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in...
Nature· 3 days agoA study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.
Sustained attention operates via dissociable neural mechanisms across different eccentric locations...
Nature· 5 days agoIn primates, foveal and peripheral vision have distinct neural architectures and functions. However, it has been debated if selective attention operates via the same or different neural mechanisms ...
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis - Nature...
Nature· 6 days agoThe endoplasmic reticulum (ER) is a major site of lipid peroxidation during ferroptosis. Here authors show that the ER protein IRE1α determines ferroptosis induction via regulating glutathione synthesis independent of the unfolded protein response.
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated...
Nature· 6 days agoHypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain ...
Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways...
Nature· 4 days agoADAR2 KO mice are protected against several HFD–induced metabolic defects, show reduced hepatic lipid accumulation, improved hepatic insulin signaling, and increased pyruvate tolerance and glycogen synthesis, by activation of AMPK signaling pathways.
TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5...
Nature· 5 days agoNon-alcoholic steatohepatitis (NASH) is rapidly surpassing viral hepatitis as the primary cause of hepatocellular carcinoma (HCC). However, understanding of NASH-progressed HCC remains poor, ...
Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie...
Nature· 4 days agoDesigning a supervised latent factor framework for snRNA-seq human brain, the authors find distinct Alzheimer’s-predictive gene modules across celltypes, suggesting subcelltype disease progression trajectories.