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Catalytic atroposelective synthesis - Nature Catalysis
Nature· 7 days agoAtropisomerism is an expanding target of asymmetric catalysis. In this Review, recent advances in atroposelective synthesis under catalytic control are highlighted with a focus on general strategies that provide high versatility and modularity.
A disinhibitory microcircuit of the orbitofrontal cortex mediates cocaine preference in mice -...
Nature· 5 days agoBoth clinical and animal studies showed that the impaired functions of the orbitofrontal cortex (OFC) underlie the compulsive drug-seeking behavior of drug addiction. However, the functional ...
Microbubble ultrasound maps hidden signs of heart disease
Nature· 19 hours agoUltrasound imaging of blood flow through coronary arteries.
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients - British...
Nature· 3 days agoTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC patients ...
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies - Cell...
Nature· 5 days agoForkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients ...
Estimating neutrosophic finite median employing robust measures of the auxiliary variable -...
Nature· 3 days agoOur study explores neutrosophic statistics, an extension of classical and fuzzy statistics, to address the challenges of data uncertainty. By leveraging accurate measurements of an auxiliary ...
3D genomic mapping reveals multifocality of human pancreatic precancers - Nature
Nature· 6 days agoQuantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in...
Nature· 3 days agoSensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates ...
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy - Nature
Nature· 6 days agoUnder stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial cells ...
Sex and gender discussions don't need to be toxic
Nature· 6 days agoThe science of sex and gender is too often misinterpreted and weaponized. Now, three experts cut through the misinformation in search of a positive...
