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Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult...
Nature· 18 hours agoReverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as ...
Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal...
Nature· 18 hours agoThis study focuses on how endothelial cells contribute to ECM accumulation of renal fibrosis and suggests that MDK promotes ACTA2 expression by stabilizing the C/EBPβ protein.
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression - Communications...
Nature· 18 hours agoPNUTS-deficient mice exhibit multiorgan failure and vascular leakage. PNUTS regulates SEMA3B, suggesting a target for endothelial aging.
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 18 hours agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients - British...
Nature· 4 days agoTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC patients ...
Estimating neutrosophic finite median employing robust measures of the auxiliary variable -...
Nature· 4 days agoOur study explores neutrosophic statistics, an extension of classical and fuzzy statistics, to address the challenges of data uncertainty. By leveraging accurate measurements of an auxiliary ...
A disinhibitory microcircuit of the orbitofrontal cortex mediates cocaine preference in mice -...
Nature· 6 days agoBoth clinical and animal studies showed that the impaired functions of the orbitofrontal cortex (OFC) underlie the compulsive drug-seeking behavior of drug addiction. However, the functional ...
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in...
Nature· 4 days agoSensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates ...
3D genomic mapping reveals multifocality of human pancreatic precancers - Nature
Nature· 7 days agoQuantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies - Cell...
Nature· 6 days agoForkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients ...