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Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 6 days agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression - Communications...
Nature· 6 days agoPNUTS-deficient mice exhibit multiorgan failure and vascular leakage. PNUTS regulates SEMA3B, suggesting a target for endothelial aging.
Testing functional anchor groups for the efficient immobilization of molecular catalysts on silver...
Nature· 3 days agoThiolate groups are promising anchors to immobilize catalysts, particularly on coinage metal surfaces, but the anchor group’s impact on the local adsorption configuration of the catalyst is ...
Brain-reading device is best yet at decoding ‘internal speech’
Nature· 18 hours agoTechnology that enables researchers to interpret brain signals could one day allow people to talk using only their thoughts.
Fluorescence imaging sheds light on the immune evasion mechanisms of hepatic stellate cells mediated...
Nature· 3 days agoUsing two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA...
Nature· 6 days agoRelapse is a major challenge in the treatment of drug addiction, and exercise has been shown to decrease relapse to drug seeking in animal models. However, the neural circuitry mechanisms by ...
Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult...
Nature· 6 days agoReverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as ...
Coinfection frequency in water flea populations is a mere reflection of parasite diversity -...
Nature· 2 days agoA field study of coinfection prevalence in water fleas populations revealed strong temporal pattern with prevalence level that don’t differ from random chance, suggests that coinfections in these populations governed by parasite diversity.
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation -...
Nature· 4 days agoThe N-BAR domain protein BIN1 acts as a scaffolding protein during filopodia formation in myoblast cells, together with identified co-factors.
Uncommon opsin’s retinal isomer is involved in mammalian sperm thermotaxis - Scientific Reports
Nature· 3 days agoIn recent years it became apparent that, in mammals, rhodopsin and other opsins, known to act as photosensors in the visual system, are also present in spermatozoa, where they function as highly ...