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Testing functional anchor groups for the efficient immobilization of molecular catalysts on silver...
Nature· 12 hours agoThiolate groups are promising anchors to immobilize catalysts, particularly on coinage metal surfaces, but the anchor group’s impact on the local adsorption configuration of the catalyst is ...
Fluorescence imaging sheds light on the immune evasion mechanisms of hepatic stellate cells mediated...
Nature· 12 hours agoUsing two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Uncommon opsin’s retinal isomer is involved in mammalian sperm thermotaxis - Scientific Reports
Nature· 12 hours agoIn recent years it became apparent that, in mammals, rhodopsin and other opsins, known to act as photosensors in the visual system, are also present in spermatozoa, where they function as highly ...
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation -...
Nature· 1 day agoThe N-BAR domain protein BIN1 acts as a scaffolding protein during filopodia formation in myoblast cells, together with identified co-factors.
Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders -...
Nature· 1 day agoPsychiatric disorders are highly heritable yet polygenic, potentially involving hundreds of risk genes. Genome-wide association studies have identified hundreds of genomic susceptibility loci ...
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients - British...
Nature· 6 days agoTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC patients ...
Estimating neutrosophic finite median employing robust measures of the auxiliary variable -...
Nature· 6 days agoOur study explores neutrosophic statistics, an extension of classical and fuzzy statistics, to address the challenges of data uncertainty. By leveraging accurate measurements of an auxiliary ...
Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult...
Nature· 3 days agoReverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as ...
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 3 days agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in...
Nature· 6 days agoSensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates ...