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Cubic millimetre of brain mapped in spectacular detail
Nature· 4 days agoGoogle scientists have modelled a fragment of the human brain at nanoscale resolution, revealing...
Ventral subiculum promotes wakefulness through several pathways in male mice -...
Nature· 1 day agoThe ventral subiculum (vSUB), the major output structure of the hippocampal formation, regulates motivation, stress integration, and anxiety-like behaviors that rely on heightened arousal. However ...
Coinfection frequency in water flea populations is a mere reflection of parasite diversity -...
Nature· 1 day agoA field study of coinfection prevalence in water fleas populations revealed strong temporal pattern with prevalence level that don’t differ from random chance, suggests that coinfections in these populations governed by parasite diversity.
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts -...
Nature· 4 days agoComparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
This Earth-like exoplanet is the first confirmed to have an atmosphere
Nature· 5 days ago55 Cancri e is too hot to support life as we know it, but could provide clues about Earth’s...
Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders -...
Nature· 3 days agoPsychiatric disorders are highly heritable yet polygenic, potentially involving hundreds of risk genes. Genome-wide association studies have identified hundreds of genomic susceptibility loci ...
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 5 days agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation -...
Nature· 3 days agoThe N-BAR domain protein BIN1 acts as a scaffolding protein during filopodia formation in myoblast cells, together with identified co-factors.
Subaerial weathering drove stabilization of continents - Nature
Nature· 4 days agoThe geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression - Communications...
Nature· 5 days agoPNUTS-deficient mice exhibit multiorgan failure and vascular leakage. PNUTS regulates SEMA3B, suggesting a target for endothelial aging.