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Cubic millimetre of brain mapped in spectacular detail
Nature· 4 days agoGoogle scientists have modelled a fragment of the human brain at nanoscale resolution, revealing...
Is the Internet bad for you? Huge study reveals surprise effect on well-being
Nature· 1 day agoA survey of more than 2.4 million people finds that being online can have a positive effect on...
Ventral subiculum promotes wakefulness through several pathways in male mice -...
Nature· 2 days agoThe ventral subiculum (vSUB), the major output structure of the hippocampal formation, regulates motivation, stress integration, and anxiety-like behaviors that rely on heightened arousal. However ...
Coinfection frequency in water flea populations is a mere reflection of parasite diversity -...
Nature· 2 days agoA field study of coinfection prevalence in water fleas populations revealed strong temporal pattern with prevalence level that don’t differ from random chance, suggests that coinfections in these populations governed by parasite diversity.
Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression - Communications...
Nature· 6 days agoPNUTS-deficient mice exhibit multiorgan failure and vascular leakage. PNUTS regulates SEMA3B, suggesting a target for endothelial aging.
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts -...
Nature· 5 days agoComparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
Common cold viruses circulating in children threaten wild chimpanzees through asymptomatic adult...
Nature· 6 days agoReverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as ...
Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal...
Nature· 6 days agoThis study focuses on how endothelial cells contribute to ECM accumulation of renal fibrosis and suggests that MDK promotes ACTA2 expression by stabilizing the C/EBPβ protein.
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 6 days agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Treadmill exercise training inhibits morphine CPP by reversing morphine effects on GABA...
Nature· 6 days agoRelapse is a major challenge in the treatment of drug addiction, and exercise has been shown to decrease relapse to drug seeking in animal models. However, the neural circuitry mechanisms by ...