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PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature
Nature· 5 days agoProstaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via metabolic impairment and ferroptosis.
This 30-Minute Chicken and Rice Tastes Like It's Been Simmering All Day
Simply Recipes via Yahoo News· 3 days agoCook the onions: Heat the oil in a flameproof...
Boston vs New York Stats & Past Results - NHL Game on June 05, 2021
Covers.com· 3 hours agoBoston vs New York in NHL History: Check Past Results And Stats For Insights On The Game - June 05, 2021!
Electric Mercedes-Benz G-Wagen Revealed As The Ultimate Off-Roader
Jalopnik· 6 days agoIf I could only drive one car for the rest of my life, it would be a new G-wagen. My personal most...
Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo - Nature
Nature· 5 days agoTopobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.
Antisense oligonucleotide therapeutic approach for Timothy syndrome - Nature
Nature· 5 days agoAntisense oligonucleotides effectively decrease the inclusion of exon 8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal ...
15 Best Patchouli Perfumes That Smell Seriously Luxurious
Insider Monkey via Yahoo Finance· 17 hours agoIn this article, we will discuss the 15 Best Patchouli Perfumes That Smell Seriously Luxurious. You...
PSA Detectable After Radical Prostatectomy
Medscape· 6 days agoFollowing radical prostatectomy, however, approximately 20%-40% of patients with localized disease will experience biochemical recurrence.
These 11 Products Are Like Filler for Your Under-Eye Wrinkles
Elle via Yahoo News· 3 days agoPlus, it comes in refillable packaging, making it both effective and environmentally friendly,” says...
Mechanism of single-stranded DNA annealing by RAD52–RPA complex - Nature
Nature· 5 days agoSingle-stranded DNA annealing is driven by RAD52 open rings in association with RPA.