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GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 1 day agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
A genome-wide association study identifies a locus associated with knee extension strength in older...
Nature· 1 day agoA genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
Selective venous sampling for secondary hypertension - Hypertension Research
Nature· 6 days agoThese authors contributed equally to this work.
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy...
Nature· 4 days agoΒ-lactamases-producing Escherichia coli are a widely distributed source of antimicrobial resistance (AMR), for animals and humans. Little is known about the sensitivity profile and genetic characteristics ...
Optical genome mapping unveils hidden structural variants in neurodevelopmental disorders -...
Nature· 5 days agoWhile short-read sequencing currently dominates genetic research and diagnostics, it frequently falls short of capturing certain structural variants (SVs), which are often implicated in the ...
Mercury contamination is an invisible threat to declining migratory shorebirds along the East...
Nature· 5 days agoOver one-third of the sampled shorebirds along the East Asian-Australasian Flyway are facing Hg risk. Tringa genus in South China was at the highest risk. Feather Hg was best explained by feathers ...
Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus -...
Nature· 6 days agoThis study on how Staphylococcus aureus manipulates host-derived fatty acids reveals that a bacteriallipase (Lip2) converts toxic fatty acids and cholesterol into innocuous cholesteryl esters.
Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination...
Nature· 6 days agoCutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and ...
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2...
Nature· 6 days agoImmunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer ...
Impairing hydrolase transport machinery prevents human melanoma metastasis - Communications Biology
Nature· 6 days agoAn in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.