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Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 1 day agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide...
Nature· 1 day agoGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially ...
Autistic people three times more likely to develop Parkinson's-like symptoms
Nature· 5 days agoLargest study of its kind also finds increased risk in older adults with a range of intellectual...
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 2 days agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 2 days agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 3 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 4 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 2 days agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Molecular entanglement can strongly increase basicity - Communications Chemistry
Nature· 4 days agoBrønsted basicity can be greatly enhanced by the mechanical entanglement of two or more interlocked molecular subunits within catenanes and rotaxanes. Here, the authors discuss the development ...
Cryo-EM structure of cadmium-bound human ABCB6 - Communications Biology
Nature· 1 day agoCryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.